Dynamic study on 18F-FDG uptake after oral administration

Research summary

PET imaging with 18F-FDG has been shown to be sensitive and cost-effective for evaluating cancer patients at various phases such as diagnosis, staging, and therapy assessment. Typically, 18F-FDG is administrated to patients intravenously. 18F-FDG venous injection is simple and useful in clinical routine, but venous access cannot be established in all patients, such as cancer patients with a history of extensive chemotherapy. The primary purpose of the project was to investigate the dynamic process of 18F-FDG distribution after oral administration in order to determine the optimal imaging acquisition time in human subjects. Furthermore, we are planning to investigate the absorption function of small intestine by measuring the dynamic parameter of FDG after oral administration.


Based on our data, we found the PET images should be acquired at around 60 min in the case if 18F-FDG is administrated orally for most organs. For the brain, a longer interval is required before acquisition. This finding has been published as a research paper:
Zhang K, Wang X, Hao L, Zhao Z and Han C. Dynamic observation of 18F-FDG uptake after oral administration in a healthy subject. J Nucl Med Technol. 2013,41:78-80.
This is our primary goal of this project. Furthermore, we are planning to investigate the absorption parameter of small intestine after oral administration of 18F-FDG by modelling the dynamic process of tracer in gastro-intestine system. We will set up a mathematical model firstly, then small intestine absorption parameters will be estimated based on PET dynamic images. These absorption parameters should provide more information for patients with small intestine absorption disorders.

More information

Research publication

Research info

Research title
Dynamic study on 18F-FDG uptake after oral administration

Research timeline
1.8.2013 - 1.8.2016

Inner Mongolia Medical University


China, Finland

Turku PET Centre
Turku, Finland

Funding instrument

Project budget
0 - 200,000 euros

Head of research
Chunlei Han

Research team
Kaixiu Zhang, Xuemei Wang

Inner Mongolia Medical University Hospital

Contact information
Chunlei Han

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