Research projects 2
PET imaging with 18F-FDG has been shown to be sensitive and cost-effective for evaluating cancer patients at various phases such as diagnosis, staging, and therapy assessment. Typically, 18F-FDG is administrated to patients intravenously. 18F-FDG venous injection is simple and useful in clinical routine, but venous access cannot be established in all patients, such as cancer patients with a history of extensive chemotherapy. The primary purpose of the project was to investigate the dynamic process of 18F-FDG distribution after oral administration in order to determine the optimal imaging acquisition time in human subjects. Furthermore, we are planning to investigate the absorption function of small intestine by measuring the dynamic parameter of FDG after oral administration.
Team
Kaixiu Zhang, Xuemei Wang
Carotid artery plaques are a leading cause of ischemic stroke, and carotid endarterectomy (CEA) is one of the major treatment approaches for this disease. Changes in cerebral metabolism following CEA remain unclear. The present study aimed to evaluate the effect of cerebral ammonia metabolism following CEA using 13N labeled ammonia positron emission tomography (PET) in humans. This is clinical study in human subjects. This is an international collaboration project. Since Turku PET Centre has very strong PET research experiences, we provides the research protocols to China. Partners in China performed clinical investigations based on our protocols. Furthermore, we performed data analysis and manuscript writing.
Team
Tao Wang, Yulin He, Xia Bai, Xuemei Wang