Novel system for multi-organ quantitative tissue perfusion

Research summary

The purpose of research is to develop and validate a novel system for quantitative assessment of multi-organ tissue-perfusion using a dedicated cyclotron-produced, short-lived nuclei of 15O and PET for non-invasive human and small animal studies. This system is to overcome organ-specific problems. The goal is to establish a standard package for quantitative assessment of tissue perfusion, involving ICT-based multi-modality image processing techniques.

Description

The work is based on existing similarly and uniquely equipped institutions of Osaka and Turku, including cyclotron for 15O-labeled tracer production, PET (with CT or MR), device for measuring input function, and large in-house developed software library. Established methods for tissue perfusion in key organs of human body (the myocardium, brain, skeletal muscle, adipose tissue) are to be further improved applicable to high-sensitivity 3D PET devices, with brush up of the modeling formulations for improved performance. The mathematical theories are formulated based simulations and experimental verifications for other organs, involving corrections for organ-dependent problems, with hybrid imaging techniques.

Research info

Research title
Novel system for multi-organ quantitative tissue perfusion

Research timeline
1.5.2013 - 1.4.2015

Keywords
1 5O-labeled water cardiac disease k inetic modeling metabolic disease PET phenotyping quantitation reconstruction tissue perfusion

Region
Asia

Countries
Finland, Japan

Institution
University of Turku
Turku PET Centre
Turku, Finland

Funding instrument
Academy of Finland

Project budget
200,000 - 500,000 euros

Head of research
Juhani Knuuti

Research team
(Board)Hidehiro Iida (iida@ri.vcvc.go.jp), Pirjo Nuutila, Mika Teräs, Nobuyuki Kudomi, (Main team members)Kazuhiro Koshino, Junichiro Enmi,Takashi Temma, Jarmo Teuho, Hannu Sipilä, Harri Merisaari, Marco Bucci, Kirsi Virtanen

Partners
Department of Investigative Radiology National Cerebral and Cardiovascular Centre Reseasrch Institute Osaka Japan,Department of Investigative Radiology from Kagawa University School of Medicine Kagawa Japan

Contact information
Juhani Knuuti
05005925998
juhanu.knuuti@tyks,fi

Record last updated
28.8.2015