Molecular and cellular mechanisms of restorative therapies following stroke

Research summary

Stroke is a major cause of adult disability that poses an enormous healthcare burden. It has been estimated that in Finland annual stroke-related costs (e.g., special care, rehabilitation) are 1.1 billion euros (7 % of the annual total healthcare costs).

Description

The only effective stroke therapy is thrombolysis when started within 4.5 hours of symptoms onset, but because of the narrow therapeutic time window, only few patients benefit from it. Despite extensive research, neuroprotective drugs have all failed in clinical trials. Thus, efforts focused on the pursuit of restorative therapies have emerged recently as attractive approaches for the treatment of stroke patients.

The joint project between Kuopio and Shenyang explores novel restorative therapies to enhance functional recovery in stroke animals by using behavioral tests, histology and molecular biology as outcome measures.

Research info

Research title
Molecular and cellular mechanisms of restorative therapies following stroke

Research timeline
1.4.2012 - 1.8.2020

Keywords
cerebral ischemia experimental models functional recovery restorative therapies

Region
Asia

Countries
China, Finland

Institution
University of Eastern Finland
Institute of Clinical Medicine, Neurology
Kuopio, Finland

Funding instrument
Academy of Finland, Other

Project budget
0 - 200,000 euros

Head of research
Jukka Jolkkonen

Research team
Jukka Jolkkonen, Chuansheng Zhao

Partners
Neurology, The first hospital of China Medical University, Shenyang, China

Contact information
Jukka Jolkkonen
+358-40-3552519
jukka.jolkkonen@uef.fi

Record last updated
26.8.2015