Mitochondria,as "energy factories", are responsible for creating more than 90% of the energy needed by the body to sustain life. Mitochondrial disease is a group of disorders cuased by dysfunctional mitochondria. About 1 in 4,000 children will develope this disease by the age of 10 years.Currently there is no specific method to detect this disorder clinically. This study is designated to develop a novel PET tracer for imaging mitochondrial membrane potential (MMP), which is a key inditor for moniting mitochondrial function.This is an international collaboration project with China: one researcher comes from China and part of project will be performed in China (synthesis of precursor).
Xiaoqing Zhuang, Olof Solin;Merja Haapanranta-Solin, Tove Grönroos;Juhani Knuuti
PET imaging with 18F-FDG has been shown to be sensitive and cost-effective for evaluating cancer patients at various phases such as diagnosis, staging, and therapy assessment. Typically, 18F-FDG is administrated to patients intravenously. 18F-FDG venous injection is simple and useful in clinical routine, but venous access cannot be established in all patients, such as cancer patients with a history of extensive chemotherapy. The primary purpose of the project was to investigate the dynamic process of 18F-FDG distribution after oral administration in order to determine the optimal imaging acquisition time in human subjects. Furthermore, we are planning to investigate the absorption function of small intestine by measuring the dynamic parameter of FDG after oral administration.
Kaixiu Zhang, Xuemei Wang
Vascular adhesion protein-1 (VAP-1) is an adhesion molecule and involved in leukocyte rolling, adhesion, and transmigration from the blood into sites of inflammation, which is important for the pathogenesis of atherosclerosis. VAP-1 was found and identified in Turku by Prof. Sirpa Jalkanen. In this study, we planed to investigate the relationship soluble VAP-1(sVAP-1) in serum with cardiovascular factors based on Chinese population. This is an internation collaboration project. Finland provides technical supports and VAP-1 antibodies to China. Parters in China performed population study.
Dawei Chen, Jianchang Wang, Sirpa Jalkanen, Anne Roivainen, Juhani Knuuti
Carotid artery plaques are a leading cause of ischemic stroke, and carotid endarterectomy (CEA) is one of the major treatment approaches for this disease. Changes in cerebral metabolism following CEA remain unclear. The present study aimed to evaluate the effect of cerebral ammonia metabolism following CEA using 13N labeled ammonia positron emission tomography (PET) in humans. This is clinical study in human subjects. This is an international collaboration project. Since Turku PET Centre has very strong PET research experiences, we provides the research protocols to China. Partners in China performed clinical investigations based on our protocols. Furthermore, we performed data analysis and manuscript writing.
Tao Wang, Yulin He, Xia Bai, Xuemei Wang