Mitochondria,as "energy factories", are responsible for creating more than 90% of the energy needed by the body to sustain life. Mitochondrial disease is a group of disorders cuased by dysfunctional mitochondria. About 1 in 4,000 children will develope this disease by the age of 10 years.Currently there is no specific method to detect this disorder clinically. This study is designated to develop a novel PET tracer for imaging mitochondrial membrane potential (MMP), which is a key inditor for moniting mitochondrial function.This is an international collaboration project with China: one researcher comes from China and part of project will be performed in China (synthesis of precursor).

Team

Xiaoqing Zhuang, Olof Solin;Merja Haapanranta-Solin, Tove Grönroos;Juhani Knuuti