Research projects 4
Antibiotics have made it possible for people to live longer, healthier lives. Antimicrobial resistance, however, is an increasing problem, especially in low-resource settings. This project will employ a range of methods from microbiology, clinical medicine and sociology to produce new knowledge about how AMR genes spread especially in poor West African regions, in areas where local capacity to address AMR is lagging behind, and identify ways to curb the spread of AMR. This knowledge can be utilized in national and international health policy and medical research.
The research objective is to provide quantitative data on antibiotics and antibiotic resistance genes in Indonesian environments, especially in river environments.
Antibiotic resistance (AR) is a major health threat for humans. In Europe 25 000 patients die yearly from infections caused by antimicrobial resistant bacteria. There is increasing concern that the food production chain may play a significant role as a reservoir and disseminator of AR since over 65% of the antibiotic use takes place in animal production. An important part of the dissemination of antibiotics and the evolution of AR bacterial organisms depends on either intestines of animals receiving antibiotic treatment or water environments.
In recent years, various studies have reported the occurrence of a wide range of antibiotics and antiretrovirals in different water systems. Of particular concern is the water emanating from wastewater treatment plants and informal settlements that have significant amounts of the drugs. These drugs end up in the water systems leading to a number of negative effects both terrestrial and aquatic ecosystems. Much of the work with regard to the studies is in the developed world and there is no significant studies documented in the sub-Saharan Africa where there is high disease burden, high population and limited water treatment facilities. The goal of the present study is to develop fast and reliable analytical methods for the determination of selected antibiotics and antiretroviral drugs in water selected water systems in Kenya and Finland. The removal efficiencies of the wastewater treatments plants shall be determined. The data obtained in the study shall form the basis of research on pharmaceutical and other emerging contaminants in Kenya and the evaluation of the means for their elimination in water.
Tuula Tuhkanen, Anthony Gachanja, Elijah Ngumba