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CAAST-Net Plus is a network of 25 partner organisations from all over Europe and sub-Saharan Africa, working together to support bi-regional cooperation in research and innovation. Building on the activities and outputs of the CAAST-Net project (2008-2012), CAAST-Net Plus aims to: Encourage more and better bi-regional STI cooperation for enhanced outcomes around topics of mutual interest, and particularly in relation to the global societal challenges of climate change, food security and health. Foster discussion among stakeholders for gathering informed opinion and experience about the bi-regional cooperation process, formulating and disseminating it in such a way as to be admissible to the formal bi-regional STI policy dialogue process and to programme owners. ?Through informing the bi-regional policy dialogue for mutual learning and awareness, through building support for coordinated and innovative approaches to bilateral funding of bi-regional cooperation around global challenges, brokering the public-private relationship to foster improved uptake and translation of bi-regional research partnership outputs into innovative technologies, good and services, and through dedicated mechanisms to encourage bi-regional research partnerships, CAAST-Net Plus will make invaluable contributions to the quality and scope of the Africa-Europe STI relationship for mutual benefit.